@nickush75122 years agoSuperb presentation, just what I was looking for. Clear, concise, great graphical support to your commentary... Very many thanks. 1
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@rollinstn93779 years agoDUDE, SERIOUSLY, your videos are the best. Thank you for all the great work, If I could subscribe more than once, I'd do it. You just saved me pages and pages of studyin in a 9 minute long and clear video. Thank you. 63
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@baleees6 years agoYOU ARE AMAZING! I'm such a visual person and all of this... what you're doing... Everything just stays in my brain after one time of watching! No Kidding! THANKS! 8
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@mandeepbedi41323 years agoExcellent presentation...crisp ..clear...a visual treat and much more than textbooks...simply amazing appreciate the skills... 4
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@farisalshboul9989 years agoexcellent step by step illustration as always , thanks very much Armando 1
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@yvettemorris11878 years agoThanks Armando.. you are amazing! Can you please think about posting a video of absorption, function and deficiency of vitamin B1 3
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@shelly198two7 years agoLove all your videos. This one was especially helpful. Thank You
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@gzlee23007 years agoloves all our videos. it's really helpful in understanding and all our drawings are really good. keep it up the good work
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@angelanguyen86029 years agosuperb quality!! thank you for such great work :) 2
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@ayeshahameed28597 years agoThank you so much . everything you explained was crystal clear and you explained in such a way that my mind was able to retain it just by seeing your video once. Best of luck for future and stay bless 2
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@miladsh67798 years agoYou're a great artist and also a great teacher. thank you so much for all of your works. 13
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@punthenuts6 years agoGreat description and easy to follow along!
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@123jackiez5 years agoWe have been screaming to be heard for my daughter'MS related symptoms, and your video explains so much that we can now take to our deficient doctors. Thank you to taking a very complex issue and explaining in a way that we could learn it. Amazing!!! ...12
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@DrAarka20196 years agoThank you so much. MR Armando ,I would like the hand writting more clearly 1
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@dinawahidah35166 years agoThis video is sooo interesting! Thank you for your explanation:) 2
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@Xrrrr987844 years agoThis video is fabulous and very helpful! Thanks a lot!
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@maryam0000029 years agoyou're smart and talented. thank you so much :) 3
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@payalas9 years agoWow this was very helpful and wonderful drawings! Thank you so much 10
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@Shamsanus9 years agoThank u so much !! Iam really waiting for ur book .. Good luck ! 12
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@anhenovember80438 years agoArmando, you are amazing ! It is so easy to understand all those topics you tackle through your excellent drawings and explanations. Also you have a nice humble way about you. I hope you get into teaching as doctor! Your students will thank you! ...3
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@abia15173 years agoGreat Video! Thanks AGAIN for helping me understand a topic with ease! :)
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@foruzankarimi2515 years agoThanks. .Armando. ..your videos helped me so much. ..
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@xDomglmao6 years agoComment from a different video, copy-pasted: "I'd like to add something about the weird terminology here, just details but might help someone: 1) haptocorrin = transcobalamin I (and I think formerly aka transcobalamin III) = cobalophilin = R-protein = R-factor = R-binder ("R" stands for "rapid electrophoretic mobility"). 2) The intrinsic factor receptor in the terminal ileum is also called "cubilin"; the receptor in the kidney that's responsible for the B12 reabs. is the same like the one in the terminal ileum (it is also cubilin!) with the small difference that megalin was added to this receptor (which means this receptor is more "elaborate" than the one in the terminal ileum). Also, in order for cubilin to work, you need a membrane protein that will make cubilin stay put (and will help in the endocytosis, once B12 bound), this protein being called "amnionless". 3) A mutation in cubilin or amnionless (autosomal recessive) leads to the Imerslund-Gräsbeck syndrome (syn.: defect of enterocyte intrinsic factor receptor, enterocyte cobalamin malabsorption, megaloblastic anemia 1, juvenile pernicious anemia with proteinuria due to selective intestinal malabsorption of vitamin B12), 0k in Finland/ Norway --> patients will have problems with both, B12 abs. AND reabs (remember, cubilin/ amnionless is present in both organs). 4) B12 bound to transcobalamin II (the transporter in the blood) is called "Holotranscobalamin" ("active B12"). 5) Haptocorrin is also produced in the stomach, not only by the salivary glands; and, as said in the vid, haptocorrin can bind 80% of the B12 in the blood making it unavailable for use." If you want to add/ correct something, feel free to do so ...39
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@User-to7nb5 years agoi appreciate you so much that words cannot express 1
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@dondamishitha4685 years agoReally gud explanation This video helped me a lot
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@borisbenedetti3874 years agoThx you really a lot! Your videos are amazing ! ❤️
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@youlisted12379 years agoHello “Armando Hasudungan”. You have been added on YouListed under the categories : 1) Sciences : Medicine and Biology 2) Sciences : Chemistry 5
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@ebonyharris113 years agoI wish the diagrams I drew in my notes looked this nice lol! Great video!
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@adrianar.r.4248 years agoAmazing videos!!! Thanks for sharing ;)
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@Samq6669 years agoHow about folic acid metabolism , im courious in blood-brain barrier also 7
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@evagold52219 years agoThank you, its very nice always :) Results are not only anemia, but other cells (blood, etc.) loss too. 1
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@dimitrijejovanovic30489 years agoExellent stuff mate! Just keep on going. Surely one of my favorite medical channes on YT. Could you please do review on Vitamin B1 and also its deficiency? Cheers :) 1
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@tomprovan50last yearwhat a great video the h+/k transporter is interesting. Possible low potassium may have effects as well?
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@daygumnazar9 years agoExcellent very nice job Can you put link for images?
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@Ullimately5 years agoAnything about how B12 exactly works inside the Body? and where it works, mechanisms.
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@garystanton99668 years agoAnother great video. One major cause of B12 deficiency which I was surprised you didn't mention is alcoholism. I will assume this is due to alcohol damaging the illium and preventing adequate absorption. Additionally alcoholism generally goes hand in hand with poor diet/malnutrition which also accounts for the deficiency. ...23
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@patmclean4163 years agoThis just showed up on my UTube. I have a vit b12 deficiency. Explains a lot. Thanks.
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@michaelgershon90776 years agoU know what....I give you golden buzzer
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@xeebot5 years agoCannot recommend your channel enough. Thank you!!!! 1
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@simpl67758 months agoThe most complex vitamin on Earth. thanks it helped a lot :)
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@michaelconnors88014 years agoAmerican Academy of Neurology: People with inflammatory bowel disease may also be at risk for developing nerve damage and other neurological problems, according to research that will be presented at the American Academy of Neurology’s 59th Annual Meeting in Boston, April 28 – May 5, 2007. Inflammatory bowel disease includes digestive disorders such as ulcerative colitis and Crohn’s disease that cause swelling and/or bleeding in the intestines. For the study, researchers compared 103 people with Crohn’s disease and ulcerative colitis to 51 people with other digestive disorders, such as irritable bowel syndrome, gastritis and chronic heartburn. The researchers found that those with inflammatory bowel disease were about four times more likely to develop neuromuscular conditions, including carpal tunnel syndrome and small fiber neuropathy, which causes pain and lack of feeling in the feet. Those with bowel disease were also more than six times more likely to also have a disorder called sensorimotor polyneuropathy, a nerve disease that can cause weakness, pain, and numbness. These diseases were more common in women with bowel disease than men. “Inflammatory bowel disease patients commonly suffer from several other medical conditions, like B12 deficiency and glucose intolerance. These nerve conditions we have reported are often not diagnosed by their primary care physicians,” said lead study author Francisco De Assis Gondim, MD, MSc, PhD, Professor of the Federal University of Ceará in Ceará, Brazil, and a member of the American Academy of Neurology. “People with inflammatory bowel disease who develop new symptoms, such as pain or numbness in the feet, should see a doctor.” ...
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@beckiwildeman6007 months agoI have blood cells trying to kill off my thyroid is this on the same thing track that you are speaking of?
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@lagunafishinglast yearThis guy likes to draw nice easy to follow illustrations.
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@marappags20024 years agoSir you have very good knowledge. Pl help me over come this deficiency.
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@fitybux46643 years ago What if I have a Transcobalamin deficiency? (My blood test reads as half the lower range of reference interval.) I do have some TCN2 gene variants, but I can't seem to find anything online about these specific variants. Is Transcobalamin supplementation a thing? My serum B12 is normal to high, depending on how much I supplement. ...1
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@jj30115 months agoCan you please provide the pdf for the drawing that you do in your videos please?
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@cowesmoooovers71722 years agoThis is the best interpretation of cobalamin absorption I’ve seen.
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@solimanabdo21135 years agothank you for help my and we wite more video
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@MBridge47 years agoWhat about metabolism of B12? Can you do one on that?
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@ChrisirvinAlcubilla4 weeks agoWhy vb12 didn't bind with the intrinsic factor in the stomach? Or some of it did? Just curious. Thanks
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@Igaluit5 years agoMakes you wonder what purpose Transcobalin 1 could serve by binding so much of the vitamin.
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@randomoverpopulatedworldid32862 years agoalso i heard that Prilosec stops b12 absorption so what if someone takes Prilosec for 2 years? are you b12 deficient? I've stopped taking it now and try to eat eggs everyday, but still have some anemia... i don't eat red meat and only dairy and egg and sometimes chicken. is that enough or do i need supplement? ...1
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@tonypowell2503 years agoSo which is the best brand and type of b12 ?
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@popoyoy137 years agoSo the transcobalamin I-B12 complex remains in the bloodstream? What happens to it then? Also, transcobalamin I is also in the bloodstream? 5
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@aysh_illustration_stage3 years agoWill you please tell me the point you told at . I am a bit confused at that point.
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@beingbenign26858 months agoI recently discovered you can buy B12 with intrinsic factor. Just started taking it, 🤞. Hoping it helps me and others.
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@pee29133 years agoif i happen to have ulcerative colitis would b-12 activate a flare? since there’s a chance of inflammatory with b-12
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@sajidkhanmahmood4 years agowhat is the advice for someone on omeprozole for ulcer issues and also metformin for diabetes. Will b12 supplements be adequate or will b12 have no effect because of lack of stomach acid needed for b12 to work effectively. 1
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@kartarsingh91913 years agoI have been talking suprdyn and folic acid daily since long as then deficiency was noticed.some shots were given and then d above medicine. It was 346 in August but in Nov. It is 1052. What should I do Sir.
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@patriciaslice18984 years agoWhere is the Intrinsic Factor produced?
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@chewy26329 years agoI read the letter I wrote out Please write clearly or not. But thank you very much :)
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@mem1701movies3 years agoIf you can’t absorb b12 from food can you absorb from pills? Or do you have to take shots or sublingual?
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@dibyanshusekharmohapatra99293 years agoWhat is the source of transcobalamin 1 in blood
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@latty19626 years agoHi and thank you for this video. I just got my blood work back and my B12 level is 1500. My doctor didn’t think it was a big deal. But I do. I have been exhausted lately with this annoying itch on top of my skull my elbows and knees. I am otherwise a healthy 55 years old woman athlete. I do not meat or poultry. It sounds like I am storing my b12 without getting it out to the rest of my body. This itch is unstoppable! Please help me. ...3
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@bnrvines23803 years agoOn a serious note how do you draw so well
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@createspaceone2 years agoCant the intrinsic factor be added to b12 in capsule form for people who don't have it? anyone?
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@deepun90915 years ago're supplementation, which , oral or lypsomal?
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@Jellilol014 years agoDon't forget about people with terminal ileal resections for things like Crohn's, this is also a cause of B12 deficiency
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@Shiraz6874 years agoI have been taking 2000 mcg vitamin B12 and my blood test results shows higher and what is the reasons? 1
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@yogeshpardeshi96694 years agoHi sir my b12 Level is 230 ph/ml is it fine?and I am a vegetarian... Please reply...
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@AreejFatima2963 years agoHi my b12 level is 88 I recently feel very low and disturb walking so i give a sample but the question is do menstruation periods cause b12 low level bcz i eat all type of animal origin food then why my level is too low
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@sunvavachi9 years agoI LOVE your videos...you should teach seriously. Too good. 1
Related videos for Vitamin B12 Digestion and Absorption:
appreciate the skills... 4
Can you please think about posting a video of absorption, function and deficiency of vitamin B1 3
Best of luck for future and stay bless 2
"I'd like to add something about the weird terminology here, just details but might help someone:
1) haptocorrin = transcobalamin I (and I think formerly aka transcobalamin III) = cobalophilin = R-protein = R-factor = R-binder ("R" stands for "rapid electrophoretic mobility").
2) The intrinsic factor receptor in the terminal ileum is also called "cubilin"; the receptor in the kidney that's responsible for the B12 reabs. is the same like the one in the terminal ileum (it is also cubilin!) with the small difference that megalin was added to this receptor (which means this receptor is more "elaborate" than the one in the terminal ileum). Also, in order for cubilin to work, you need a membrane protein that will make cubilin stay put (and will help in the endocytosis, once B12 bound), this protein being called "amnionless".
3) A mutation in cubilin or amnionless (autosomal recessive) leads to the Imerslund-Gräsbeck syndrome (syn.: defect of enterocyte intrinsic factor receptor, enterocyte cobalamin malabsorption, megaloblastic anemia 1, juvenile pernicious anemia with proteinuria due to selective intestinal malabsorption of vitamin B12), 0k in Finland/ Norway --> patients will have problems with both, B12 abs. AND reabs (remember, cubilin/ amnionless is present in both organs).
4) B12 bound to transcobalamin II (the transporter in the blood) is called "Holotranscobalamin" ("active B12").
5) Haptocorrin is also produced in the stomach, not only by the salivary glands; and, as said in the vid, haptocorrin can bind 80% of the B12 in the blood making it unavailable for use."
If you want to add/ correct something, feel free to do so ... 39
This video helped me a lot
You have been added on YouListed under the categories :
1) Sciences : Medicine and Biology
2) Sciences : Chemistry 5
Results are not only anemia, but other cells (blood, etc.) loss too. 1
Cheers :) 1
Can you put link for images?
People with inflammatory bowel disease may also be at risk for
developing nerve damage and other neurological problems, according to
research that will be presented at the American Academy of Neurology’s
59th Annual Meeting in Boston, April 28 – May 5, 2007.
Inflammatory bowel disease includes digestive disorders such as
ulcerative colitis and Crohn’s disease that cause swelling and/or
bleeding in the intestines. For the study, researchers compared 103
people with Crohn’s disease and ulcerative colitis to 51 people with
other digestive disorders, such as irritable bowel syndrome, gastritis
and chronic heartburn.
The researchers found that those with inflammatory bowel disease were
about four times more likely to develop neuromuscular conditions,
including carpal tunnel syndrome and small fiber neuropathy, which
causes pain and lack of feeling in the feet. Those with bowel disease
were also more than six times more likely to also have a disorder called
sensorimotor polyneuropathy, a nerve disease that can cause weakness,
pain, and numbness. These diseases were more common in women with bowel
disease than men.
“Inflammatory bowel disease patients commonly suffer from several other
medical conditions, like B12 deficiency and glucose intolerance. These
nerve conditions we have reported are often not diagnosed by their
primary care physicians,” said lead study author Francisco De Assis
Gondim, MD, MSc, PhD, Professor of the Federal University of Ceará in
Ceará, Brazil, and a member of the American Academy of Neurology.
“People with inflammatory bowel disease who develop new symptoms, such
as pain or numbness in the feet, should see a doctor.” ...
My serum B12 is normal to high, depending on how much I supplement. ... 1
I have been exhausted lately with this annoying itch on top of my skull my elbows and knees. I am otherwise a healthy 55 years old woman athlete. I do not meat or poultry.
It sounds like I am storing my b12 without getting it out to the rest of my body.
This itch is unstoppable! Please help me. ... 3
Please reply...